MH17 was flying from Amsterdam to Kuala Lumpur. Authorities are currently investigating whether the plane was shot down as it passed over volatile Eastern Ukraine airspace.
The airline says nearly 300 people were on board the flight when it crashed.
The flight tracking site, FlightAware.com, says MH17 was traveling at an altitude of 33,000 feet.
Malaysia’s prime minister expressed his feeling of shock on Twitter and announced an immediate investigation.