It happened around 1:00 a.m. along Highway 20 south of Lebanon.
Police say a 2008 GMC four-door pickup was traveling westbound when it collided with a 1999 Dodge Stratus facing east in the westbound lane.
The driver of the car, a 25 year old woman, was pronounced dead at the scene. The driver of the pickup, a 24 year old Sweet Home man, was taken to the hospital with non-life threatening injuries.
Oregon State Police are investigating the crash.